What are biologics?

Biologics may offer hope for people with chronic moderate to severe plaque psoriasis.

Biologics are different from other medications because they are made from natural sources. They are used in many different diseases, including diabetes and psoriasis. There are 2 types of biologics that are used to treat psoriasis.

RAPTIVA is a different type of biologic.

Not all biologics are the same. In fact, there are 2 types of biologics that treat psoriasis: T-cell modulators and tumor necrosis factor (TNF) inhibitors. They are both made from proteins, and are both taken through injections-but the way they work is very different.

To understand biologics, start with the T-cells.

• "My doctor explained how RAPTIVA worked differently. It affects your T-cells, and that's why I decided to try it."*
• Tim S, RAPTIVA patient, 7 months
• *Individual results may vary.

T-cells are immune system cells with many functions. When your T-cells are functioning properly, they help to protect you from infection. In psoriasis, overactive T-cells send messages to your skin cells, telling them to multiply faster and faster. The result is the red, inflamed, or silvery, scaly build-up of skin called plaque psoriasis.

T-cell modulators work on the T-cell.

RAPTIVA is a T-cell modulator, a biologic that attaches directly to overactive T-cells. Once it does this, it prevents the T-cells from sending messages to the skin cells. When the T-cells become less active, the skin cells will multiply at a more normal rate.

TNF inhibitors work around the T-cell.

The other type of biologic used in psoriasis treatment is called a TNF inhibitor. It works by attaching to one type of chemical messenger (TNF) released by the T-cells. TNF is one of the messengers that causes inflammation in psoriasis.

If you've tried another biologic and haven't been satisfied with the results, talk to your dermatologist about RAPTIVA. The results you have with RAPTIVA may be different than the results you've had with any other biologic because it works on your psoriasis in a different way.

• "My physician and I talked about [another biologic], but I thought it was geared more toward psoriatic arthritis-I don't have that disease."*
• Lee, RAPTIVA patient, 6 months
• *Individual results may vary.

Talk to your doctor today. Find out if RAPTIVA could be the right biologic for you.